'New malaria vaccine found 100 per cent effective

Updated on : 17-02-2017 04:40 PM
A new vaccine for malaria is up to 100 per cent effective when assessed at 10 weeks after last dose, according to the results of a clinical trial.


The vaccine called Sanaria PfSPZ-CVac incorporated fully viable - not weakened or otherwise inactivated - malaria pathogens together with the medication to combat them.

Malaria parasites are transmitted by the bite of female Anopheles mosquitoes. The Plasmodium falciparum parasite is responsible for most malaria infections and almost all deaths caused by the disease worldwide.

Most of the previous vaccines which have been tried involved the use of individual molecules found in the pathogen. However, they were unable to provide sufficient immunity to the disease.

The study by University of Tubingen in Germany in collaboration with the biotech company Sanaria involved 67 healthy adult test persons, none of whom had previously had malaria.

The best immune response was shown in a group of nine test persons who received the highest dose of the vaccine three times at four-week intervals.

At the end of the trial, all nine of these individuals had 100 per cent protection from the disease.

"That protection was probably caused by specific T-lymphocytes and antibody responses to the parasites in the liver," said Professor Peter Kremsner.

The researchers analysed the bodies' immune reactions and identified protein patterns which will make it possible to further improve malaria vaccines, Kremsner added.

(KG-17/2)

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